Here we demonstrate that cyclophilin A CyPA, a member of the immunophilin family, is secreted by VSMCs in response to oxidative stress and mediates extracellular signal regulated kinase ERK1 2 activation and VSMC growth by reactive oxygen species augmentin adult dosing Intralesional rituximab therapy has been used in the treatment of primary B cell cutaneous lymphoma with equivalent response rates, fewer adverse effects, and lower cost as compared to systemic rituximab treatment 107